DNA Sequence and Histone Core Composition Control the Unwrapping of DNA from Nucleosome Core Particles
نویسندگان
چکیده
منابع مشابه
Local DNA sequence controls the cooperativity and asymmetry of DNA unwrapping from nucleosome core particles
DNA is tightly wrapped around histone proteins in nucleosome core particles (NCPs), yet must become accessible for processing in the cell. This accessibility, a key component of transcription regulation, is influenced by the properties of both the histone proteins and the DNA itself, in addition to other factors. Here we focus on how DNA sequence affects unwrapping from NCPs, and thus accessibi...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2019
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2018.11.1179